Cheap Flights from Santiago to Guayaquil

Q: How many flights are there a week from Santiago to Guayaquil?

As of May 2025, there are no flights flying from Santiago to Guayaquil.

Q: When is the cheapest time to fly from Santiago to Guayaquil?

The cheapest month to fly from Santiago to Guayaquil is usually May 2025.

Q: Can I get a direct flight from Santiago Airport to Guayaquil Airport?

No airlines currently offer direct flights between Santiago Airport and Guayaquil Airport. Most routes have one or more stops.

Q: How can I find the best flight deal to Guayaquil?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Guayaquil but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

Q: When is the best time to book flights to Guayaquil?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Guayaquil is around 40 days in advance, so don’t leave your flight to the last minute.

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Flight deals from Santiago to Guayaquil

Looking for a cheap last-minute deal or the best return flight from Santiago to Guayaquil? Find the lowest prices on one-way and return tickets right here.

Santiago to Guayaquil: Alternative routes

Compare routes to Guayaquil below. You may find an airport to fly into that's cheaper, faster, or easier.

Finding cheap flights from Santiago to Guayaquil: Frequently asked questions

How many flights are there a week from Santiago to Guayaquil?

When is the cheapest time to fly from Santiago to Guayaquil?

Can I get a direct flight from Santiago Airport to Guayaquil Airport?

How can I find the best flight deal to Guayaquil?

When is the best time to book flights to Guayaquil?

How to find cheap flights to Guayaquil from Santiago

Looking for cheap tickets from Santiago to Guayaquil? Here are a few tips on how to secure the best flight price and make your journey as smooth as possible.

Simply hit 'search'. From British Airways to international carriers like Emirates, we compare all major airlines along with the most popular online travel agents to find the cheapest plane tickets from Santiago to Guayaquil. And with us there are no hidden fees - what you see is what you pay.
Compare flight deals to Guayaquil from Santiago from over 1,000 providers. Then choose the cheapest or fastest plane tickets.
Flex your dates to find the best Santiago-Guayaquil ticket prices. If you are flexible when it comes to your travel dates, use Skyscanner's 'Whole month' tool to find the cheapest month, and even day to fly to Guayaquil from Santiago.
Set up a Price Alert. You can easily track the fare of your cheap Santiago-Guayaquil flights by creating an alert. Whenever prices go down or up, you'll get an email or push notification to help make sure you get the best possible flight deal.
Fly without stops. Only interested in direct flights between Santiago and Guayaquil? Make sure to tick 'Direct flights only' when performing a search. If there are direct flights available on the route, these will appear in the results.
Find the cheapest Business class flights from Santiago and Guayaquil. We scour the internet for the best Business, Premium Economy and First Class flight fares to Guayaquil, too. Check the difference in price as you search – you might just chance upon a last-minute low fare. Note that not all cabin classes are available for every destination or airline.
Include nearby airports in your search. Widen your search for Santiago to Guayaquil flight deals by selecting the "add nearby airports" option. This will allow you to see flight prices for all the nearest airports at your departure point and your destination and could help you save next time you travel.

Combine your flight to Guayaquil from Santiago with hotels and car hire

Once you've secured your cheap flight ticket from Santiago to Guayaquil, discover the best prices and exclusive rates for hotels in Guayaquil or nearby. You can also compare hundreds of car hire companies in one go so that you get the best car hire price for your trip.