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Cheap Flights from Santo Domingo to Panama City

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Compare Santo Domingo to Panama City flight deals

Find the cheapest month or even day of the year to fly to Panama City

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Flight deals from Santo Domingo to Panama City

Looking for a cheap last-minute deal or the best return flight from Santo Domingo to Panama City? Find the lowest prices on one-way and return tickets right here.
Panama City.$498 per passenger.Departing Tue, 8 Jul, returning Thu, 17 Jul.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Tue, 8 Jul, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Thu, 17 Jul, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $498, select.
Panama City.$498 per passenger.Departing Tue, 20 May, returning Fri, 30 May.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Tue, 20 May, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Fri, 30 May, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $498, select.
Panama City.$498 per passenger.Departing Wed, 30 Apr, returning Sun, 4 May.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Wed, 30 Apr, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 4 May, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $498, select.
Panama City.$508 per passenger.Departing Sat, 5 Apr, returning Sun, 6 Apr.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Sat, 5 Apr, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 6 Apr, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $508, select.
Panama City.$508 per passenger.Departing Wed, 25 Jun, returning Sun, 29 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Wed, 25 Jun, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 29 Jun, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $508, select.
Panama City.$508 per passenger.Departing Wed, 25 Jun, returning Wed, 2 Jul.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Wed, 25 Jun, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 2 Jul, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $508, select.
Panama City.$510 per passenger.Departing Thu, 21 Aug, returning Thu, 28 Aug.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Thu, 21 Aug, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Thu, 28 Aug, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $510, select.
Panama City.$510 per passenger.Departing Fri, 26 Sep, returning Mon, 3 Nov.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Santo Domingo Las Americas on Fri, 26 Sep, arriving in Panama City Tocumen International.Inbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 3 Nov, arriving in Santo Domingo Las Americas.Price includes taxes and charges.From $510, select.

Find the cheapest month to fly from Santo Domingo to Panama City

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Santo Domingo to Panama City flights are currently cheapest in May.
Apr
from $508
May
from $498
Jun
from $508
Jul
from $498
Aug
from $510
Sep
from $801
Oct
from $576
Nov
Find prices
Dec
from $696
Jan
Find prices
Feb
Find prices
Mar
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Direct flights from Santo Domingo to Panama City

Alternative Santo Domingo to Panama City routes

Looking for the cheapest, fastest or easiest route from Santo Domingo to Panama City? You could fly into the following airports instead.

Santo Domingo to Panama City: Flight information

The things to know before you go.
Cheapest flight found$498
Cheapest month to flyApril
Average flight time2 hrs, 36 mins
Most popular airlineCopa
Average flights per week61

Finding cheap flights from Santo Domingo to Panama City: Frequently asked questions

There are 3 airports in Panama City: Panama City Paitilla, Balboa and Panama City Tocumen International.
The best price we found for a return flight from Santo Domingo to Panama City is $498. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.
2 hours and 36 minutes is the average flight time from Santo Domingo to Panama City.
Copa, Turkish Airlines and KLM fly direct from Santo Domingo to Panama City.
As of April 2025, there are 244 flights per week flying from Santo Domingo to Panama City.
The cheapest month to fly from Santo Domingo to Panama City is usually April 2025.
If you're flying from Santo Domingo, the cheapest airport near Panama City is Panama City Tocumen International – which is 17.9 km away from the centre of Panama City. We've found flights into this airport from $498.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Santo Domingo to Panama City on Wednesday, 30 April 2025.
Yes – the average flight time is 2 hours and 36 minutes.
We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Panama City but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.
We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Panama City is around 40 days in advance, so don’t leave your flight to the last minute.
In April, the average temperature is usually around 28°C. May is typically the warmest month in Panama City, when it usually averages around 29°C. You can expect the least rain in February. The coldest month is October, with temperatures averaging 25°C. The rainiest month is June.
The cheapest airline that flies to Panama City is Avianca. And the cheapest airline that flies to Balboa Airport is Copa.

Travelling from Santo Domingo to Panama City: what you need to know

  • There are a couple of main airports you can start your trip from in Santo Domingo. Check out your options departing from Las Americas International Airport (SDQ) or Dr. Joaquin Balaguer International Airport (JBQ) when planning your flight from Santo Domingo to Panama City.

  • Hop off your plane in Panama City at Tocumen International Airport (PTY) or Panama Pacifico Airport (BLB).

  • The average length of a direct flight from Santo Domingo to Panama City is 2 hours 36 minutes. Panama City's timezone is UTC-5, making Panama City 1 hour behind Santo Domingo.

  • With 34 weekly flights between the two airports, Las Americas International Airport (SDQ) to Tocumen International Airport (PTY) is the busiest route. Board the first flight from Santo Domingo to Panama City with Copa Airlines at 06:16. If you're keen to get more out of your day before leaving, the last flight from SDQ to PTY is with Copa Airlines at 17:50.

  • To ensure you catch your flight from Santo Domingo to Panama City, allow plenty of time to check in and drop off your luggage. Turning up two hours before international departures and one hour before domestic flights is the standard rule.

  • Travelling during a popular month like August? School holidays and other high seasons can mean longer lines at check-in and security. Be extra cautious and get there up to four hours before an international flight and two hours before domestic departures.

  • You will need an embassy visa for Panama if you hold a passport from Dominican Republic and are visiting for tourism purposes. Travel documentation and visa requirements can change. So before you book your cheap flights from Santo Domingo to Panama City, check with your airline and the destination country's local consulate or embassy for the most up-to-date information.

Flying from Santo Domingo

Las Americas International Airport (SDQ)

  • Set off from Las Americas International Airport (SDQ) on a nonstop flight from Santo Domingo to Panama City. From SDQ, you can land directly at Tocumen International Airport (PTY).

  • You can book a direct flight from Santo Domingo to Panama City with Copa Airlines. This popular carrier offers services from SDQ.

  • We make it easy to plan a flight from Santo Domingo to Panama City that includes a stopover. To see all your options departing from Las Americas International Airport, deselect 'Direct flights only.' Next, pick a flight with a stop long enough to explore the city of your choice. Some popular stopovers include:

    • Punta Cana International Airport (PUJ)

    • Juan Santamaria International Airport (SJO)

    • El Dorado International Airport (BOG)

  • Central Santo Domingo to SDQ is approximately 32 kilometres. Depending on traffic conditions, it'll take you about 31 minutes to reach there if you're catching a cab, ride-sharing or driving.

  • Catching an early flight from Santo Domingo to Panama City? Avoid the stress of rushing to the terminal (and enjoy a little extra shut-eye) by choosing one of these stays near Las Americas International Airport:

Dr. Joaquin Balaguer International Airport (JBQ)

  • Make the most of your holiday with a stopover on your flight from Santo Domingo to Panama City. Visit family or friends or tick a new city off your bucket list. Whatever you choose to do, check out these stops between Las Americas International Airport and Panama City:

    • Punta Cana International Airport (PUJ)

    • Juan Santamaria International Airport (SJO)

    • El Dorado International Airport (BOG)

  • JBQ is approximately 19 kilometres from central Santo Domingo. It'll take 27 minutes or so to get to the airport driving from the city centre.

  • Getting to the airport on time before your flight from Santo Domingo to Panama City is a lot easier when you stay near Dr. Joaquin Balaguer International Airport. Consider booking a room at Confortable, Quiet And Secure the night before flying out.

Arriving in Panama City

Tocumen International Airport (PTY)

Marcos A. Gelabert International Airport (PAC)

How to find the cheapest flights from Santo Domingo to Panama City

  • At the moment, $216 is the lowest price we've found for a one-way ticket from Santo Domingo to Panama City. The cheapest price for a return flight is $498. Bear in mind fares can change due to demand at the time of booking.

  • To snag cheap tickets from Santo Domingo to Panama City, book your journey 4 months before your planned departure.

  • The cheapest month for flight tickets from Santo Domingo to Panama City is December. Compare prices using the 'Whole month' tool to find the cheapest day to fly.

  • Log into your online account or use the app to create a Price Alert. We'll notify you right away if there's a better deal on this route. It's easy to do, and it'll save you the hassle of checking for cheap tickets from Santo Domingo to Panama City every day.

  • Use filters to tailor your flights from Santo Domingo to Panama City. Select your ideal arrival and departure times, number of stops and airlines. Or sort your results by 'Cheapest' to find the best deals.

Best time to go to Panama City

  • June is the most popular month for flights from Santo Domingo to Panama City. To skip the crowds, go to Panama City in February.

  • Lock in your flight from Santo Domingo to Panama City for March if you'd like to visit the city during its warmest month. Expect temperatures in Panama City to range from 21ºC to 32ºC.

  • Search for cheap tickets from Santo Domingo to Panama City in February if you want to travel in cooler conditions. Temperatures are at their lowest around then, ranging between 22ºC and 31ºC on average.

More about Panama City

  • When it comes to looking for somewhere to lay your head, you'll find the best stays in Panama City right here. Browse these hotels after you've booked your flight from Santo Domingo to Panama City:

  • Panama Canal Museum and Casco Viejo are just a couple of the top attractions to put on your Panama City travel itinerary. Continue your sightseeing adventures at Cinta Costera.

Complete your Panama City trip with a car rental

  • We use the same magic that helped you find your cheap flight from Santo Domingo to Panama City to track down awesome deals on car rentals. Search for your ride in seconds and compare your options in one place. Plus we give you all the info you need to drive in Panama City, from the most popular car type to the average daily price.

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Plan the rest of your trip from Santo Domingo to Panama City

Prices shown on this page are estimated lowest prices only. Found in the last 45 days.