$606 Cheap Flights from Panama City to Sao Paulo in 2025

Compare Panama City to Sao Paulo flight deals

Find the cheapest month or even day of the year to fly to Sao Paulo

Book the best Sao Paulo fare with no extra fees

Flight deals from Panama City to Sao Paulo

Looking for a cheap last-minute deal or the best return flight from Panama City to Sao Paulo? Find the lowest prices on one-way and return tickets right here.

Sao Paulo.$606 per passenger.Departing Wed, 30 Apr, returning Mon, 5 May.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Wed, 30 Apr, arriving in Sao Paulo Guarulhos.Inbound indirect flight with Avianca, departs from Sao Paulo Guarulhos on Mon, 5 May, arriving in Panama City Tocumen International.Price includes taxes and charges.From $606, select.

Sao Paulo.$634 per passenger.Departing Mon, 31 Mar, returning Mon, 7 Apr.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 31 Mar, arriving in Sao Paulo Guarulhos.Inbound indirect flight with Avianca, departs from Sao Paulo Guarulhos on Mon, 7 Apr, arriving in Panama City Tocumen International.Price includes taxes and charges.From $634, select.

Sao Paulo.$634 per passenger.Departing Sun, 6 Apr, returning Thu, 10 Apr.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 6 Apr, arriving in Sao Paulo Guarulhos.Inbound indirect flight with Avianca, departs from Sao Paulo Guarulhos on Thu, 10 Apr, arriving in Panama City Tocumen International.Price includes taxes and charges.From $634, select.

Sao Paulo.$662 per passenger.Departing Sun, 1 Jun, returning Mon, 30 Jun.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Sun, 1 Jun, arriving in Sao Paulo Guarulhos.Inbound indirect flight with Avianca, departs from Sao Paulo Guarulhos on Mon, 30 Jun, arriving in Panama City Tocumen International.Price includes taxes and charges.From $662, select.

Sao Paulo.$666 per passenger.Departing Mon, 11 Aug, returning Mon, 25 Aug.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 11 Aug, arriving in Sao Paulo Guarulhos.Inbound indirect flight with Avianca, departs from Sao Paulo Guarulhos on Mon, 25 Aug, arriving in Panama City Tocumen International.Price includes taxes and charges.From $666, select.

Sao Paulo.$695 per passenger.Departing Mon, 16 Jun, returning Fri, 4 Jul.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 16 Jun, arriving in Sao Paulo Guarulhos.Inbound indirect flight with Avianca, departs from Sao Paulo Guarulhos on Fri, 4 Jul, arriving in Panama City Tocumen International.Price includes taxes and charges.From $695, select.

Sao Paulo.$735 per passenger.Departing Mon, 12 May, returning Fri, 16 May.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Mon, 12 May, arriving in Sao Paulo Guarulhos.Inbound indirect flight with Avianca, departs from Sao Paulo Guarulhos on Fri, 16 May, arriving in Panama City Tocumen International.Price includes taxes and charges.From $735, select.

Sao Paulo.$737 per passenger.Departing Thu, 13 Mar, returning Mon, 24 Mar.Return flight with Avianca.Outbound indirect flight with Avianca, departs from Panama City Tocumen International on Thu, 13 Mar, arriving in Sao Paulo Guarulhos.Inbound indirect flight with Avianca, departs from Sao Paulo Guarulhos on Mon, 24 Mar, arriving in Panama City Tocumen International.Price includes taxes and charges.From $737, select.

Find the cheapest month to fly from Panama City to Sao Paulo

We’re always keeping an eye on fares, so you can find the best one in seconds. It looks like Panama City to Sao Paulo flights are currently cheapest in April.

Mar

Apr

May

Jun

Jul

Aug

Sep

Oct

Nov

Dec

Jan

Feb

Direct flights from Panama City to Sao Paulo

Alternative Panama City to Sao Paulo routes

Looking for the cheapest, fastest or easiest route from Panama City to Sao Paulo? You could fly into the following airports instead.

Panama City to Sao Paulo: Flight information

The things to know before you go.

Cheapest flight found	$606
Cheapest month to fly	April
Average flight time	6 hrs, 43 mins
Most popular airline	Copa
Average flights per week	858

Finding cheap flights from Panama City to Sao Paulo: Frequently asked questions

How many airports are there in Sao Paulo?

There are 4 airports in Sao Paulo: Sao Paulo Congonhas, Sao Paulo Guarulhos, Sao Paulo Viracopos, and Sao Jose Dos Campos.

How much are return flights from Panama City to Sao Paulo?

The best price we found for a return flight from Panama City to Sao Paulo is $606. This is an estimate based on information collected from different airlines and travel providers over the last 4 days and is subject to change and availability.

How long does it take to fly from Panama City to Sao Paulo?

6 hours and 43 minutes is the average flight time from Panama City to Sao Paulo.

Which airlines fly direct from Panama City to Sao Paulo?

Copa, Emirates and Azul Airlines fly direct from Panama City to Sao Paulo.

How many flights are there a week from Panama City to Sao Paulo?

As of March 2025, there are 858 flights per week flying from Panama City to Sao Paulo.

When is the cheapest time to fly from Panama City to Sao Paulo?

The cheapest month to fly from Panama City to Sao Paulo is usually March 2025.

Which is the cheapest airport to fly into in Sao Paulo?

If you're flying from Panama City, the cheapest airport near Sao Paulo is Sao Paulo Guarulhos – which is 20.4 km away from the centre of Sao Paulo. We've found flights into this airport from $606.

Which upcoming date is cheapest to fly from Panama City to Sao Paulo on?

After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Panama City to Sao Paulo on Wednesday, 30 April 2025.

Can I get a direct flight from Panama City to Sao Paulo?

Yes – the average flight time is 6 hours and 43 minutes.

How can I get the best flight deal from Panama City to Sao Paulo?

We show every price from over 1,200 airlines and travel agents, comparing them all so you don’t have to. If you know you want to fly to Sao Paulo but you’re not ready to book, set up a Price Alert. We’ll track prices for you, and let you know when they rise or fall.

When is the best time to book flights to Sao Paulo?

We crunched all the numbers in our flight calendar and it looks like the cheapest time to book a flight to Sao Paulo is around 40 days in advance, so don’t leave your flight to the last minute.

What’s the weather like in Sao Paulo?

In March, the average temperature is usually around 23°C. February is typically the warmest month in Sao Paulo, when it usually averages around 27°C. You can expect the least rain in August. The coldest month is July, with temperatures averaging 12°C. The rainiest month is January.

Which is the cheapest airline to fly from Panama City to Sao Paulo with?

The cheapest airline that flies to Sao Paulo is Avianca. And the cheapest airline that flies to Sao Paulo Guarulhos Airport is Copa.

Travelling from Panama City to Sao Paulo: what you need to know

There are two main airports to choose from in Panama City. Explore your options leaving from Tocumen International Airport (PTY) or Panama Pacifico Airport (BLB) when booking your flight from Panama City to Sao Paulo.
Hop off your plane in Sao Paulo at Sao Paulo-Guarulhos International Airport (GRU) or Viracopos Airport (VCP).
A direct flight from Panama City to Sao Paulo takes an average of 7 hours 1 minute. The timezone in Sao Paulo is UTC-3, which is 2 hours ahead of Panama City.
Tocumen International Airport (PTY) to Sao Paulo-Guarulhos International Airport (GRU) is the most traveled route between these two cities. There are 40 flights a week to pick from. If you prefer a later start to the day, the last flight from Panama City to Sao Paulo is with Copa Airlines at 21:42. Choose the first PTY to GRU departure operated by Copa Airlines at 11:50 to maximise your time in Sao Paulo.
Give yourself enough time to catch your flight from Panama City to Sao Paulo. As a rule of thumb, arrive two hours before international departures and an hour ahead for domestic flights.
Flying over a peak time like June? Public holidays and other popular periods can lead to longer queues and delays at check-in and security. Play it safe and arrive up to four hours before international flights and two hours before a domestic departure.
If you have a passport from Panama and are travelling to Brazil for tourism purposes, you won't need a visa. However, visa and entry requirements may differ based on your reason for visiting and are subject to change. For the latest information, check with your destination's nearest consulate or embassy before reserving a cheap flight from Panama City to Sao Paulo.

Flying from Panama City

Tocumen International Airport (PTY)

You can reserve a direct flight from Panama City to Sao Paulo taking off from Tocumen International Airport (PTY). Start your journey at PTY and end it at Sao Paulo-Guarulhos International Airport (GRU).
Book your direct flight from Panama City to Sao Paulo with Copa Airlines. This top carrier offers services from PTY.
Consider adding a stopover to potentially save on your flight from Panama City to Sao Paulo. Simply uncheck 'Direct flights only' when browsing departures from Tocumen International Airport. Break up your trip (and maybe save some cash) by stopping at one of these airports:
- El Dorado International Airport (BOG)
- Ministro Pistarini Airport (EZE)
- Jorge Chavez International Airport (LIM)
Travelling from central Panama City to PTY takes around 1 hour and 5 minutes on public transport. If you drive, ride-share or grab a cab, you'll cover the 21 kilometres in 21 minutes or so, depending on traffic conditions.
Want a convenient hotel close to Tocumen International Airport? If you're boarding an early flight from Panama City to Sao Paulo, these stays will have you moments from your departure lounge:

Panama Pacifico Airport (BLB)

Break up your flight from Panama City to Sao Paulo with a stop so you can recharge or cross a new place off your list. Some top stopovers between Tocumen International Airport and Sao Paulo are:
- El Dorado International Airport (BOG)
- Ministro Pistarini Airport (EZE)
- Jorge Chavez International Airport (LIM)
BLB is around 16 kilometres from central Panama City. It takes 22 minutes or so to reach the airport driving from the city centre.
You're off on holiday, so why not extend it with an extra night away? Consider checking in to one of these hotels near Panama Pacifico Airport the day before your flight from Panama City to Sao Paulo:

Arriving in Sao Paulo

Sao Paulo-Guarulhos International Airport (GRU)

Sao Paulo-Guarulhos International Airport (GRU) is around 26 kilometres from central Sao Paulo. With a cab or in your own car rental, the drive is about 32 minutes.
Travelling to the centre by public transport will take you roughly 1 hour and 22 minutes.
Reserve a hotel close to GRU if you're taking a late flight from Panama City to Sao Paulo. Check in to one of these options and avoid the hassle of a long transfer:

Sao Paulo/Congonhas Airport (CGH)

The centre of Sao Paulo is about 10 kilometres from Sao Paulo/Congonhas Airport (CGH). As soon as your flight from Panama City to Sao Paulo has landed and you've navigated your way to arrivals, the drive should take about 17 minutes.
If you're travelling on public transport, it'll take about 34 minutes.
There are some comfortable stays ready to welcome you near CGH. Tuck yourself in after your flight from Panama City to Sao Paulo at any of these perfectly located options:

How to find the cheapest flights from Panama City to Sao Paulo

The lowest price we've found for a one-way ticket from Panama City to Sao Paulo is $396. For a return flight on this route, the best price is $606. Depending on when you book and the availability, these fares may change.
Book 6 months before your departure date. After crunching the numbers on our calendar, this is how far you should book ahead to find cheap tickets from Panama City to Sao Paulo.
Schedule your trip for February. That's the cheapest month for flight tickets from Panama City to Sao Paulo. If you're flexible with your travel dates, use the 'Whole month' tool to see the cheapest price across each month.
Getting a cheap ticket from Panama City to Sao Paulo is easy with Price Alerts. Simply create one of these automatic alerts and we'll notify you when the price has dropped.
Use filters to tailor your flights from Panama City to Sao Paulo. Pick your ideal departure and arrival times, airlines and number of stops. Or sort your results by 'Cheapest' to see the best deals.

Best time to go to Sao Paulo

It's time to work out your trip dates for your flight from Panama City to Sao Paulo. July is the busiest month for a trip to Sao Paulo. If you prefer a quieter atmosphere, go in May.
The warmest month in Sao Paulo is February, with temperatures ranging between 18ºC and 28ºC. Book your flights from Panama City to Sao Paulo in this month if you like this kind of weather.
July sees average temperatures of between 12ºC and 25ºC. Look for cheap tickets from Panama City to Sao Paulo sometime around then if you'd rather travel in cooler conditions.

More about Sao Paulo

When it comes to looking for somewhere to rest your head, you'll find the top stays in Sao Paulo right here. Browse these options once you've booked your flight from Panama City to Sao Paulo:
Sao Paulo Museum of Art and Ibirapuera Park are just the start of the major attractions to add to your Sao Paulo to-do list. Keep the adventure rolling by checking out Paulista Avenue.

Complete your Sao Paulo trip with a car rental

Finding you a cheap flight from Panama City to Sao Paulo isn't our only party trick. Check out our car rentals in Sao Paulo and explore on your own terms. We find deals from trusted car rental companies and put them all in one place. Instantly compare offers and then book with no fees.